Senior Scientific Officer/Cell Culturist
Dr Steven Vayro graduated from the University of Central Lancashire with a BSc (Hons) degree in biochemistry/chemistry. He then went on to do a Ph.D. in biochemistry at Aberystwyth University, Wales. From there he established an extensive research career working at a number of universities both in the U.K. and abroad. Areas of interest covered many aspects of research into the structure/function analysis of specific membrane transport proteins, (mainly the intestinal sodium dependent D-glucose cotransporter (SGLT1)), as well as a renal sodium dependent D-glucose cotransporter (SGLT2), a renal proton-dipeptide transporter, renal chloride channel, and a salivary gland sodium dependent phosphate transporter (NaPi1). Intracellular regulation pathways were investigated as well as a molecular characterisation of the SGLT1 promoter to identify a minimal region necessary to support transcription. A novel fully functional c-myc N-terminal tagged SGLT1 isoform confirmed the extracellular topology of the carrier whilst a functional A166C SGLT1 mutant isoform proved a key region for the Na+-binding domain.
For several years, Dr Vayro held a part-time lecturing post in the School of Pharmacy & Biomedical Sciences, at the University of Portsmouth, teaching undergraduates in Pharmacy, Pharmaceutical Sciences, Pharmacology, Biomedical Science and Healthcare Sciences. Lately, his research interests have drawn him into neuro-pharmacology and neuro-oncology fields where he has been investigating the role of neurotransmitters (ATP and Glutamate) on P2X and P2Y receptors within white matter astrocytes, using calcium sensitive dyes and fluorescent confocal imaging techniques.
Dr Vayro has currently joined the Brain Tumour Research Group here at the University of Portsmouth. His role includes the management and development of human brain tumour cell resources including the establishment of primary cultures from human derived biopsies; their analysis using molecular (i.e. Short Tandem Repeat (STR) based DNA profiling) and protein biomarkers, as well as undertaking research in support of the Centre’s activities.