Job Vacancies

ZZ601504 – Senior Research Fellow

Faculty of Science, School of Pharmacy & Biomedical Sciences

Employment type:  Fixed-term contract (fixed-term to 30 September 2018 or the earlier return of the substantive post holder) to cover a period of maternity leave

Employment basis:  Full-time

Salary:  £38,833 – £47,722 per annum

Post number:  ZZ601504

Date published:  11 October 2017

Closing date:  05 November 2017

Interview date:  21 November 2017

Investigating the role of mitochondrial dysregulation in brain tumours

We are seeking to recruit a talented postdoctoral scientist with experience in molecular and cellular biology to provide maternity cover for our current Mitochondria and Metabolism Sub-theme Leader within the Brain Tumour Research Centre.

This post is available for up to 30 September 2018 (or the early return of the post holder) to work on active and ongoing projects in an exciting and growing research area that investigates the role of mitochondria and related parameters in brain tumours, in particular the most common and malignant primary brain tumour in adults, glioblastoma. The project capitalises on existing publications and unpublished data that is yielding novel insights into the role of mitogenomic elements and enzymes in glioblastoma cell behaviours, including drug sensitivity.

The Senior Research Fellow will be part of the Brain Tumour Research Centre Mitochondria and Metabolism Sub-theme within the School of Pharmacy and Biomedical Sciences, at the University of Portsmouth. The Brain Tumour Research Centre has recently been refurbished and has dedicated laboratories with multiple pieces of equipment and established assays for histology, cell culture, cellular and molecular biology, imaging, in addition to a brand new metabolic suite.

Candidates should have a PhD in a related field of molecular and/or cellular biology and experience in cell culture, protein/ nucleotide extraction, PCR, western blotting, gene modulation, enzyme activity assays and cell functional assays and related techniques. The collection, collation, analysis and interpretation of descriptive and quantitative data should be demonstrated with publications in good quality refereed journals. Additional demonstrable research knowledge, particularly of mitochondrial genetics and biology and neuro-oncology would be a significant advantage.

The Senior Research Fellow should be able to manage the day-to-day running of a number of related research projects including assisting the work of junior researchers. Good communication skills will be key to the successful working with associated team members, including internal and external collaborators. The Senior Research Fellow will be expected to acquire new data and to analyse existing data in order to complete publications, and to play a lead role in drafting of these manuscripts.

Informal enquiries are actively encouraged and can be made to Dr Rhiannon McGeehan (current Mitochondria and Metabolism Sub-theme lead) 02392 842118, rhiannon.mcgeehan@port.ac.uk or Professor Geoff Pilkington, Head of Centre, geoff.pilkington@port.ac.uk

For detailed information about the vacancy, please select this link: ZZ601504 – Senior Research Fellow.docx

To apply click here

ZZ004259 – Senior Scientific Officer

Faculty of Science,  School of Pharmacy and Biomedical Sciences

Employment type:  Fixed term contract ending 30 September 2019

Employment basis:  Full time

Salary:  £34,520 – £37,706 per annum

Post number:  ZZ004259

Date published:  13 October 2017

Closing date:  05 November 2017

Interview date:  28 November 2017

Candidates are invited to apply for a fixed term, full time post in the Brain Tumour Research Centre within the School of Pharmacy and Biomedical Science.

An experienced cell culturist/researcher at the level of Senior Scientific Officer is required to undertake a new post within the Brain Tumour Research Centre at the University of Portsmouth. The Centre is currently composed of postdoctoral researchers, PhD students and technical staff along with research internship and project students. The Centre is core funded by the charity, Brain Tumour Research who are also supporting this new post. The new cell culturist/researcher will hold responsibility for establishment of biopsy-derived brain tumour cell resources, DNA finger printing, maintaining records and overseeing a cell bank database. They will play an integral role within the Centre’s current research programmes.

The successful candidate will hold a relevant UG degree and preferably Master’s degree or PhD and will undertake a wide range of techniques from within the Centre’s very well-equipped cellular, molecular, and metabolic laboratories. The post is supported for 2 years in the first instance.

For further information please contact Professor Geoff Pilkington – geoff.pilkington@port.ac.uk

For detailed information about the vacancy, please select this link: ZZ004259 – Senior Scientific Officer.docx

To apply click here

ZZ003736 – Research Fellow

Faculty of Science, School of Biological Sciences

Employment type:  Fixed-term contract for 18 months

Employment basis:  Part-time (0.50 fte)

Salary:  £17,260 – £18,853 (£34,520 – £37,706 x 0.50 FTE) per annum

Post number:  ZZ003736

Date published:  13 October 2017

Closing date:  05 November 2017

Interview date:  23 November 2017

Investigating the role of mitochondrial mutations in brain tumours

We are seeking to recruit a talented postdoctoral scientist with experience in molecular and cellular biology to join our cross-Institute of Biological and Biomedical Sciences project, which combines the research areas of Structural Biology and Brain Tumour Mitochondria and Metabolism.

This post is available for 18 months to work within the Molecular Biophysics group and the Brain Tumour Research Centre of Excellence on an ongoing project that investigates the role of mitochondrial mutations in brain tumours, in particular the most common and malignant primary brain tumour in adults, glioblastoma. The project combines mutation discovery from patient tumour samples using next generation sequencing technologies and associated bioinformatics, with functional candidate identification using in silico 3D protein structural mapping and analysis, followed by validation using a suite of in vitro functional assays using patient tumour-derived cell cultures. This integrated approach is yielding novel insights into the role mitochondrial mutations in glioblastoma cell behaviours, including drug sensitivity.

The Fellow will be a member of both the Structural Biology Group within the School of Biological Sciences and the Brain Tumour Mitochondria and Metabolism Group within the School of Pharmacy and Biomedical Sciences, both at the University of Portsmouth. The in silico (bioinformatic and 3D structural analysis) will be conducted in the state-of-the-art Molecular Biophysics Laboratories, while the mitochondrial genome preparation for next generation sequencing, cell culture and related in vitro functional assays will be conducted in the recently refurbished Brain Tumour Research Centre, both research areas within the Institute of Biological and Biomedical Sciences (IBBS).

As a collective, the Fellow will have access to a range of in-house facilities including computing infrastructure and the bioinformatics group required for the next generation sequencing and 3D structural analysis, as well as dedicated laboratories, with multiple pieces of equipment and established assays for: histology, cell culture, cellular and molecular biology, imaging, in addition to a brand new metabolic suite.

Candidates should have a PhD or equivalent professional experience in a related field of molecular and/or cellular biology. Experience in protein structural biology, nucleotide extraction, PCR, cell culture and in vitro functional assays or related techniques is essential. The collection, collation, analysis and interpretation of descriptive and quantitative data should be demonstrated with publications in a refereed journals. Additional postdoctoral research knowledge, particularly of mitochondrial genetics and biology, next generation sequencing and neuro-oncology, would be a significant advantage.

The Fellow should be able to manage the day-to-day running of a research project including assisting the work of junior researchers. Good communication skills will be key to the successful working between both groups and associated team members. The Fellow will be expected to acquire new data to complete publications, to analyse existing data and to participate in the drafting of manuscripts.

Informal enquiries are actively encouraged and can be made to Professor John McGeehan (Director of IBBS) 02392 842042, John.McGeehan@port.ac.uk

For detailed information about the vacancy, please select this link: ZZ003736 – Research Fellow.docx