Tumour Micro-environment

Brain tumours arise in an orchestrated fashion by interacting with host ‘normal’ brain cells – it is as if the cancer cells influence the host cells to help them in their destructive ambition. Additionally, if that is not bad enough, both cell types will adapt to therapies over time (tumour resistance). There are four current areas here on which we concentrate; angiogenesis (and the effects of anti-angiogenesis approaches on downstream tumour biology), invasion (molecular determinants of the various ways tumour cells spread within and around the brain as well as between different organs in the body), immunology (exploring the chemical cross-talk between immune surveillance cells and brain tumour cells) and finally, pericytes (these enigmatic cells not only form part of the BBB, but also exist within brain tumours where they play an essential role in co-option with glioma cells to regulate tumour survival).