Publications

Zaynah Maherally, Helen L. Fillmore, Sim Ling Tan, Suk Fei Tan,† Samah A. Jassam, Friederike I. Quack, Kathryn E. Hatherell, and Geoffrey J. Pilkington. Real-time acquisition of transendothelial electrical resistance in an all-human, in vitro, 3-dimensional, blood–brain barrier model exemplifies tight-junction integrity. The FASEB Journal article fj.201700162R. Published online September 7, 2017

Moriconi C, Palmieri V, Santo R, Tornillo G, Papi M, Pilkington G, Spirito M, Gumbleton M. INSIDIA: a FIJI Macro Delivering High‐throughput and High‐content Spheroid Invasion Analysis. Biotechnology Journal. 2017 Aug 8.

Weller M, van den Bent M, Tonn JC, Stupp R, Preusser M, Cohen-Jonathan-Moyal E, Henriksson R, Le Rhun E, Balana C, Chinot O, Bendszus M, Pilkington GJ. European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. The Lancet Oncology. 2017 May 5.

Hill R, Madureira PA, Ferreira B, Baptista I, Machado S, Colaço L, Dos Santos M, Liu N, Dopazo A, Ugurel S, Adrienn A. TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT. Nature Communications. 2017;8.

Hill R, Murray SA, Maherally Z, Higgins SC, Pilkington GJ. Drug Repurposing to Circumvent Chemotherapy Resistance in Brain Tumours. InResistance to Targeted Therapies Against Adult Brain Cancers 2016 (pp. 107-144). Springer International Publishing.

Vouri M, Croucher DR, Kennedy SP, An Q, Pilkington GJ, Hafizi S. Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells. Oncogenesis. 2016 Oct 1;5(10):e266.

Rooprai HK, Martin AJ, King AN, Appadu UD, Jones H, Selway RP, Gullan RW, Pilkington GJ. Comparative gene expression profiling of ADAMs, MMPs, TIMPs, EMMPRIN, EGF-R and VEGFA in low grade meningioma. International Journal of Oncology. 2016 Oct 18.

Valvona CJ. The therapeutic potential of targeting brain tumour metabolism through LDHA. Neuro-Oncology. 2016;10(6):7-11

Song Z, Laleve A, Vallières C, McGeehan JE, Lloyd RE, Meunier B. Human mitochondrial cytochrome b variants studied in yeast: not all are silent polymorphisms. Biochimica et Biophysica Acta (BBA)-Bioenergetics. 2016 Aug 31;1857:e44-5.

Jassam SA, Maherally Z, Smith JR, Ashkan K, Roncaroli F, Fillmore HL, Pilkington GJ. TNF-alpha enhancement of CD62E mediates adhesion of non-small cell lung cancer cells to brain endothelium via CD15 in lung-brain metastasis. Neuro-oncology. 2016 May 1;18(5):679-90

Smith JR, Maherally Z, Higgins SC, An Q, Fillmore HL, Pilkington GJ. AFM observation of heightened cell periphery of high-grade glioblastoma cell lines. BioNanoScience. 2016 Mar 1;6(1):47-53.

Maherally Z, Smith JR, Ghoneim MK, Dickson L, An Q, Fillmore HL, Pilkington GJ. Silencing of CD44 in glioma leads to changes in cytoskeletal protein expression and cellular biomechanical deformation properties as measured by AFM nanoindentation. BioNanoScience. 2016 Mar 1;6(1):54-64.

Jassam SA, Maherally Z, Fillmore HL, Pilkington GJ. NSCLC cell adhesion to and transmigration through brain endothelium in brain metastasis. World Federation of Neuro-oncology Society Magazine (OUP), 2016; Volume 1 Issue 1 p2 – p6

Valvona CJ, Fillmore HL, Nunn PB, Pilkington GJ. The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor. Brain pathology. 2016 Jan;26(1):3-17. PubMed PMID: 26269128.

Toman P, Lien CF, Ahmad Z, Dietrich S, Smith JR, An Q, Molnár É, Pilkington GJ, et al. Nanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: Preparation and in vitro investigation. Acta biomaterialia. 2015 Sep;23:250-62. PubMed PMID: 25983313.

Lloyd RE, Keatley K, Littlewood DT, Meunier B, Holt WV, An Q, Pilkington GJ, et al. Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma. Neuro-oncology. 2015 Jul;17(7):942-52. PubMed PMID: 25731774. Pubmed Central PMCID: 4474231.

Ferreira BI, Hill R, Link W. Special review: caught in the crosshairs: targeted drugs and personalized medicine. The Cancer Journal. 2015 Nov 1;21(6):441-7.

Leite DM, Barbu E, Pilkington GJ, Lalatsa A. Peptide Self-Assemblies for Drug Delivery. Current topics in medicinal chemistry. 2015;15(22):2277-89. PubMed PMID: 26043734.

Lalatsa A, Moreira Leite D, Pilkington GJ. Nanomedicines and the Future of Glioma. Oncology News. 2015;10(2):51-7.

Vouri M, An Q, Birt M, Pilkington GJ, Hafizi S. Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells. Oncotarget. 2015 Jun 30;6(18):16183.

Higgins SC, Fillmore HL, Ashkan K, Butt AM, Pilkington GJ. Dual targeting NG2 and GD3A using Mab-Zap immunotoxin results in reduced glioma cell viability in vitro. Anticancer research. 2015 Jan;35(1):77-84. PubMed PMID: 25550537.

Pilkington GJ. Neuro-oncology supplement. Oncology News, 2015:1 (ISSN 1751-4975).

Higgins SC, Bolteus AJ, Donovan LK, Hasegawa H, Doey L, Al Sarraj S,. Al Sarraj S, King A, Ashkan K, Roncaroli F, Fillmore HL, Pilkington GJ. Expression of the chondroitin sulphate proteoglycan, NG2, in paediatric brain tumors. Anticancer research. 2014 Dec;34(12):6919-24. PubMed PMID: 25503117.

An Q, Fillmore HL, Vouri M, Pilkington GJ. Brain tumor cell line authentication, an efficient alternative to capillary electrophoresis by using a microfluidics-based system. Neuro-oncology. 2014 Jan;16(2):265-73. PubMed PMID: 24335698. Pubmed Central PMCID: 3895385.

Pilkington GJ. Neuro-oncology in the UK, Europe and beyond; the role of EANO. Oncology News, Volume 8 Issue 5 November/December 2013.

Lloyd RE, McGeehan JE. Structural Analysis of Mitochondrial Mutations Reveals a Role for Bigenomic Protein Interactions in Human Disease. PLoS One. 2013 Jul 9;8(7):e69003. doi: 10.1371/journal.pone.0069003.

Maherally Z, Fillmore HL, Pilkington GJ. The Blood Brain Barrier in Cerebral Metastasis. Oncology News, Volume 8 Issue 3 July/August 2013.

Lehnus KS, Donovan LK, Huang X, Zhao N, Warr TJ, Pilkington GJ, et al. CD133 glycosylation is enhanced by hypoxia in cultured glioma stem cells. International journal of oncology. 2013 Mar;42(3):1011-7. PubMed PMID: 23340741.

Birks SM, Donovan LK, and Pilkington GJ. Mammalian Cell Culture In: Tools and Techniques in the Biomolecular Sciences. Eds Divan A and Royds J Oxford University Press (978-0-19-969556-0 March 2013).

Donovan LK, Pilkington GJ. CD133: holy of grail of neuro-oncology or promiscuous red-herring? Cell proliferation. 2012 Dec;45(6):527-37. PubMed PMID: 23106300.

Fillmore HL. International Collaborations: an essential and noble manner to advance scientific research to the bedside (bench to bedside). Oncology News, Volume 7 Issue 5 November/December 2012, p138

Donovan LK, Fillmore HL and Pilkington GJ. Developments in Genomic characterisation of Medulloblastomas; contributions to the advancement of therapeutic stratification for children with brain cancer. Oncology News, Volume 7 Issue 5 November/December 2012, pp148-149.

Maherally Z, Smith JR, An Q, Pilkington GJ. Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? PloS one. 2012;7(2):e30691. PubMed PMID: 22363471. Pubmed Central PMCID: 3281850.

Donovan LK, Potter NE, Warr T, Pilkington GJ. A Prominin-1-Rich Pediatric Glioblastoma: Biologic Behavior Is Determined by Oxygen Tension-Modulated CD133 Expression but Not Accompanied by Underlying Molecular Profiles. Translational oncology. 2012 Jun;5(3):141-54. PubMed PMID: 22741033. Pubmed Central PMCID: 3384268.

Little SE, Popov S, Jury A, Bax DA, Doey L, Al-Sarraj S, Jurgensmeier JM, Jones C. Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual exclusivity in variable proportions reflective of individual tumor heterogeneity. Cancer research. 2012 Apr 1;72(7):1614-20.

Chidambaram, H.L. Fillmore, T.E. Van Meter, C.L. Dumur, W.C. Broaddus. Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness. Journal of Neurosurgery. 2012 Apr;116(4):843-53

Lien CF, Molnar E, Toman P, Tsibouklis J, Pilkington GJ, Gorecki DC, et al. In vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles as permeating vectors for the blood-brain barrier. Biomacromolecules. 2012 Apr 9;13(4):1067-73. PubMed PMID: 22409486.

Pilkington GJ. The British Neuro-oncology Society: Thirty years of endeavour to champion an under-recognised discipline. Oncology News 6 (2): 46-47 (2011) ISSN 1751-4975.

Pilkington GJ. News from the British Neuro-Oncology Society (BNOS): Where Have We Come Since 1980? EANO Magazine, Volume 2 (2012) Issue 3 e-ISSN 2224-3453

Parker KA, Glaysher S, Hurren J, Knight LA, McCormick D, Suovouri A, Amberger-Murphy V, Pilkington GJ, Cree IA. The effect of tricyclic antidepressants on cutaneous melanoma cell lines and primary cell cultures. Anti-cancer drugs. 2012 Jan;23(1):65-9. PubMed PMID: 21897201.

Bell S and Pilkington GJ. The nature and clinical consequences of metastatic spread to the brain: current research approaches to better understand and circumvent the problem. (NCRI Supplement) Oncology News 6 (5) 6-7 (November 2011).

Birks SM, Danquah JO, King L, Vlasak R, Gorecki DC, Pilkington GJ. Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma. Neuro-oncology. 2011 Sep;13(9):950-60. PubMed PMID: 21807667. Pubmed Central PMCID: 3158019.

Hatherell K, Couraud PO, Romero IA, Weksler B, Pilkington GJ. Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models. Journal of neuroscience methods. 2011 Aug 15;199(2):223-9. PubMed PMID: 21609734.

Higgins SC, Steingrimsdottir H, Pilkington GJ. Human, mouse or rat? Species authentication of glioma-derived cell cultures. Journal of neuroscience methods. 2010 Dec 15;194(1):139-43. PubMed PMID: 20951163.

Higgins SC, Pilkington GJ. The in vitro effects of tricyclic drugs and dexamethasone on cellular respiration of malignant glioma. Anticancer research. 2010 Feb;30(2):391-7. PubMed PMID: 20332444.

 

N-O front page July 2015